Unable to Launch PCM 11

Having read through the forum I have tried all of the following steps with completely updated drivers and a reinstall of PCM too but still can't get the game to start. It has never successfully started for me.

"black or white screen at the start, or crash
For many reasons, Pro cycling Manager may not start properly. Here are some tricks to try to solve the problem :
-launch the game in admin mode;
-shut down the antivirus : some antivirus simply cut the applications with no warning;
-launch the game from Program files instead of autorun.
-skip the start videos : A codec problem may prevent the game from starting. You can rename the 'videos' folder in your installation folder.
-Change the 'my documents' folder : rename your 'Pro Cycling Manager 2011' folder in 'my documents', but don't delete it ! if the game starts, a new Pro Cycling Manager 2011 folder will be built. You can then try to add the files from the former folder and identify which file is corrupted. Most of the time, the murderer is 'local.cdb'."

I try to start the game and it just locks up. I can't even stop the process using Task Manager and have to resort to manually holding down the power button to reboot as shuting down doesn't even work.

I am running:

Windows: Vista Home Premium (6.0, Build 6002)
Display: ATI Radeon HD4800 with the latest drivers (10/11/2011)
Sound: Realtek High Definition Audio with the latest drivers (13/12/2011)
Motherboard: P5K
Processor: Intel Core 2 Duo E6550 @ 2.33GHz
Memory: 4GB

A little gutted to not even be able to start the game so any help greatly appreciated, thanks